Article Dans Une Revue Nature Immunology Année : 2004

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

Vincent Bischoff
  • Fonction : Auteur
Cécile Vignal
  • Fonction : Auteur
Ivo Boneca
  • Fonction : Auteur
Tatiana Michel
  • Fonction : Auteur
Julien Royet

Résumé

The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.

Dates et versions

hal-05256638 , version 1 (15-09-2025)

Identifiants

Citer

Vincent Bischoff, Cécile Vignal, Ivo Boneca, Tatiana Michel, Jules Hoffmann, et al.. Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Nature Immunology, 2004, 5 (11), pp.1175-1180. ⟨10.1038/ni1123⟩. ⟨hal-05256638⟩
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